8-night Lower Mississippi River Cruise

October 3, 2025

American Cruise Lines: American Serenade

Memphis/New Orleans

Vacation Offer ID 1507118

Reference this number when contacting our travel specialist.

Call for pricing

Request a Quote View Details

The Signature Collection – Exclusive Amenities
The Signature Collection Sailings offer Exceptional Value and Exclusive Amenities.

Cruise Inclusions

Cruise
Meals
Entertainment and more

Destination Guide
Suggested Shore Excursions

Destination	Arrival	Departure
Memphis Memphis 10/03/2025 The largest city in Tennessee offers everything a curious tourist, hungry gourmet, or history buff could want to do and see at attractions that include music museums, art galleries, Mississippi riverboat tours, and the Memphis Zoo. Be sure to visit Graceland, and then visit the other side of Memphis at the W.C. Handy Museum, Shelby Farms, the largest urban park in the country, or the "twisted" National Ornamental Metal Museum. In the heart of "Blues City", you'll find the Peabody Memphis, one of the city's most popular attractions. Legendary, charming, and elegant are adjectives that perfectly describe this grand hotel, where its famous Peabody Ducks march to and from the Grand Lobby.,	10/03/2025	10/03/2025
Mississippi River Cruising Mississippi River Cruising 10/04/2025 Enjoy the warmth of the Mississippi River sun while lounging in the Queen of the Mississippi's many luxurious spaces, including the sun deck or Paddlewheel Lounge.,	10/04/2025	10/04/2025
River Cruising	10/05/2025	10/05/2025
Vicksburg Vicksburg 10/06/2025 In Vicksburg, you'll find Southern hospitality in its most authentic form. This is a city bursting at the seams with history at some of its most poignant turns, art at its most creative angles, food at its finest flavors, and outdoor adventure at its most thrilling. With sweeping views of the Mississippi River, Vicksburg perfectly blends Southern culture and heritage along with hallowed stories of Civil War battles.,	10/06/2025	10/06/2025
Natchez Natchez 10/07/2025 Sitting high on the bluff above the mighty Mississippi River rests Natchez, a city 300 years in the making. At first glance, Natchez appears to be frozen in time, with perfectly preserved homes and buildings that remind us of days gone by. In fact, over 1,000 of its historic structures are listed in the National Register of Historic Places. Upon closer inspection, you will soon discover that Natchez, while indeed a reflection of the past, is also alive in the present – filled with arts, music, culture, events, commerce, and natural beauty.,	10/07/2025	10/07/2025
St. Francisville St. Francisville 10/08/2025 This quaint southern town is filled with simple pleasures and unique treasures. Located on the bluffs of the Mississippi River, St. Francisville has been called "one of the 200 most beautiful small towns in America". During your stop in St. Francisville, taking a stroll through its historic center awakens an awareness of history, with two centuries of architecture and lifestyles. Nearby plantations beckon you back to a time when coquettish southern belles and their chivalrous suitors sipped mint juleps on the shady porches of these grand estates.,	10/08/2025	10/08/2025
Baton Rouge Baton Rouge 10/09/2025 Experience the wonder of Baton Rouge, Louisiana's capital city, one that is rich in culture and heritage. Known affectionately as the Red Stick, Baton Rouge is home to legendary Louisiana Cajun cuisine, fascinating plantation tours, and a variety of attractions and events. There is everything you would expect to find in a state capital, but with a down-home flavor that is part of its seductive charm. Baton Rouge is a destination with true Southern hospitality. Let us give you the grand tour of one of the most historic, vibrant and unforgettable cities in the South.,	10/09/2025	10/09/2025
Houmas House Houmas House 10/10/2025 Located on the Mississippi River between the historic cities of New Orleans and Baton Rouge, Oak Alley Plantation has been called the Grande Dame of the Great River Road. A quarter-mile canopy of giant live oak trees forms an impressive avenue that leads you to this classic Greek-revival style antebellum home. This imposing mansion has been restored to its 19th-century glory, a noble tribute to those who left an indelible mark on this rich river region.,	10/10/2025	10/10/2025
New Orleans New Orleans 10/11/2025 Nowhere is this city's spirit more evident than in the famed French Quarter, with its architectural mix of Spanish, French, Creole, and American styles. Also known as Vieux Carré - or the "Quarter" to locals - it sits on a bend of the Mississippi River on some of the highest grounds in New Orleans. Intimate and special, the city's oldest neighborhood has exerted a spell over writers and artists since the time of Mark Twain, Lafcadio Hearn, and John James Audubon. During your visit to New Orleans, you will begin to understand the city's unique ability to integrate history, absorb new influences, and fashion one-of-a-kind delights that continue to amaze not only much of the world, but also the inhabitants of New Orleans themselves.,	10/11/2025	10/11/2025

American Cruise Lines: American Serenade

American Cruise Lines is pleased to announce the American Serenade, one of the newest ships in the revolutionary modern riverboat series. The overture to American Serenade’s cruise season will begin on the legendary Mississippi River in 2023. Like her sister ship American Symphony, the 175-passenger American Serenade introduces an updated modern interior design, integrating an elegant and refined aesthetic with the tradition for the spacious comfort found aboard all of our ships. Drawing inspiration from the geography across America, the new interior design highlights natural textural elements and serene color palettes.

Ship Statistics

Maiden Voyage: 2023
Passenger Capacity: 175
Number of Staterooms: 91

Number of Suites: 16
Wheelchair Accessible: Yes

Suite

Veranda Suite (Private Balcony) (VS) Call for pricing

Category: VS
Deck 4

With a generous 405 sq. ft. of relaxing space, each Veranda suite includes a private walk-out balcony to enjoy the panoramic views. Considered one of the finest staterooms on any cruise ship, guests will enjoy full-size bathrooms and large living area with sliding glass door.

Grand Suite (Private Balcony) (GS) Call for pricing

Category: GS
Deck 4

The luxurious Grand Suite measures 650 sq. ft. and offers panoramic views through floor-to-ceiling glass windows. Sliding glass doors lead out to a private balcony complete with a private dining area, the perfect place to enjoy breakfast room service or watch the sun set. Each Grand Suite features a separate bedroom and living area, ideal for gathering with family and friends after an invigorating day of exploration.

Balcony

Single (Private Balcony) (SGB) Call for pricing

Category: SGB
Deck 4
Deck 3
Deck 2

Perfect for the solo traveler, the Single staterooms offer all of the amenities you expect from a fine hotel. At 250 sq. ft., these staterooms have spacious bathrooms and large sliding glass doors that lead to a private balcony.

Balcony Stateroom (AAR) Call for pricing

Category: AAR
Deck 1

AAR staterooms on the main deck offer complete comfort with approximately 275 sq. ft. of living space. Enjoy a full-size bathroom, large picture window, and door leading out to a furnished private balcony. These staterooms also feature a large sitting area, ideal for getting together with friends.

Balcony Stateroom (AAM) Call for pricing

Category: AAM
Deck 3

Located on the third deck, these spacious staterooms feature commanding views of the passing river landscapes. At 350 sq. ft., there is plenty of room to enjoy the tasteful comfort of your surroundings. These staterooms have all the comforts of a fine hotel and feature floor-to-ceiling sliding glass doors with a private balcony to offer panoramic views from every angle.

Balcony Stateroom (AAC) Call for pricing

Category: AAC
Deck 2

AAC staterooms are conveniently located on the second deck and offer all of the comforts of a fine hotel. Complete with a private balcony and floor-to-ceiling sliding glass doors, these staterooms provide spectacular views of the surrounding landscape. At 316 sq. ft., these staterooms also offer a sitting area, desk and full-size bathrooms.

Prices are per person based on double occupancy. Pricing on some sailings may reflect special limited time offers, not combinable with any other offers/discounts. Valid on new bookings only.

All fares are quoted in US Dollars.

Deck 5